Smart polymers driven by multiple and tunable hydrogen bonds for intact phosphoprotein enrichment

Supramolecular polymers with tunable topologies via hierarchical coordination-driven self-assembly and hydrogen bonding interfaces.

A powerful strategy to obtain complex supramolecular materials is the bottom-up construction of noncovalently bound materials by hierarchical self-assembly. This assembly process involves stepwise, uniform increases to the architectural complexity of a substrate, starting from discrete precursors and growing in dimensionality through controlled reactivity to a final product. Herein, two orthogo...

Multiple Hydrogen-Bonded Supramolecular Polymers

Tunable organic photocatalysts for visible-light-driven hydrogen evolution.

Photocatalytic hydrogen production from water offers an abundant, clean fuel source, but it is challenging to produce photocatalysts that use the solar spectrum effectively. Many hydrogen-evolving photocatalysts are active in the ultraviolet range, but ultraviolet light accounts for only 3% of the energy available in the solar spectrum at ground level. Solid-state crystalline photocatalysts hav...

Energetic Effects of Multiple Hydrogen Bonds. Implications for Enzymatic Catalysis

The rate enhancements obtained by enzymes often require greater than 20 kcaVmol of stabilization that is specific to the transition state. Inspection of active sites suggests that enzymes often use multiple interactions with substrate groups undergoing charge rearrangement to help provide this preferential stabilization. We have analyzed the deprotonation, in DMSO, of benzoic acids with one or ...

enrichment of intact peripheral blood dendritic cells by immunomagnetic depletion

introduction: enrichment of intact peripheral blood dendritic cells (dcs) has been done using rosette and immunomagnetic depletion techniques. material and methods: peripheral blood mononuclear cells were separated using ficoll density gradient centrifugation and t lymphocytes were depleted through reaction with aet- treated sheep red blood cells. the remaining cells were depleted from lineage ...